Natural Product Polyphenols of Relevance to Human Health
نویسندگان
چکیده
منابع مشابه
Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
Dihydrofolate reductase (DHFR) is the subject of intensive investigation since it appears to be the primary target enzyme for antifolate drugs. Fluorescence quenching experiments show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG) are potent inhibitors of DHFR with dissociation constants (K(D))of 0.9 and 1.8 microM, respectiv...
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Polyphenols have been shown to have some of the neuroprotective effects against neurodegenerative diseases. These effects are attributed to a variety of biological activities, including free radical scavenging/antioxidant and anti-inflammatory and anti-apoptotic activities. In this regard, many efforts have been made to study the effects of various well-known dietary polyphenols on spinal cord ...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2004
ISSN: 1388-0209,1744-5116
DOI: 10.3109/13880200490893519